It was a dramatic draw on Friday which saw both English sides, Manchester City and Liverpool, face one another as well as a heavyweight clash between Real Madrid and Juventus.
Barcelona, however, will theoretically have a slightly easier time against Serie A outfit Roma, who knocked Shakhtar Donetsk out on away goals in the Round of 16, especially as their star forward has already enjoyed great success in Italy.
Against Inter Milan (1W, 1D, 1L), Udinese (1W), AC Milan (4W, 3D, 1L) and Juventus (2W, 2D, 1L), the Argentine has scored ten goals from 17 matches, at an average of 0.59 a game.
Against Roma specifically, Messi has scored twice in two meetings (1W, 1D) and is yet to lose to the 'Giallorossi' - something Barcelona will be hoping continues when the two sides battle it out at the Camp Nou in the first leg on April 4.