The Frenchman is set to field Cristiano ronaldo and Gareth Bale up fron together, with the midfield roles reserved for his most trusted lieutenants: Casemiro, Modric, Kroos and Isco.
There is not a doubt in the Real boss' mind as to which team he should field against the German side, who are yet to concede a single goal in the Bundesliga so far this season.
Despite their travails in the league, 'Los Blancos' cannot afford to slip up in the Champions League as they look to defend their title.
A defeat in Germany would leave Zidane's side facing a tricky double-header against Tottenham Hotspur with the possibility of dropping down the the Europa League then becoming a real danger.
Zidane will play his strongest available side, though Marcelo and Benzema will both miss out once again through injury.
Nacho and Bale will start in place of the injured duo as Real look to return to the rigidity of a good old-fashioned 4-4-2.
With Casemiro, Modric, Kroos and Isco manning the engine room and with Bale and Ronaldo enjoying free reign up top, it promises to be a much more balanced line-up than the 4-3-3 that Zidane experimented with in Benzema's absence.