It prormises to a huge week of international football. From Europe to South America and everwhere in between there's plenty at stake.
Up to 13 teams could mathematically seal their place at next summer's World Cup between Thursday and Saturday.
Here's what each one requires in order to do so:
THURSDAY:
GERMANY: Will qualify with a draw.
POLAND: Must win and hope that Montenegro and Denmark draw.
ENGLAND: Will qualify with a win, or in the event that Slovakia do not win, a draw.
URUGUAY: A Win will see them qualify.
COLOMBIA: Will qualify if they win, Chile fail to win and Argentina and Peru draw.
FRIDAY:
SERBIA: A win will see them qualify. If they draw, they must hope that both Wales and Ireland do not win. If they lose, they need Wales to lose and Ireland to fail to win.
SPAIN: Will qualify if they win and Italy don't or if they draw and Italy lose.
COSTA RICA: Need only a draw and could still qualify with a loss providing that the USA do not win.
PANAMA: Must win and hope that Honduras don't win.
SATURDAY:
NIGERIA: A win or a draw will see them qualify.
TUNISIA: Will qualify if they win and the DR Congo do not.
FRANCE: Need to win and hope that Sweden lose.
SWITZERLAND: Need to win and hope that Portugal don't or draw and hope that Portugal lose.