Southampton: The 'Saints' will once against be without defender Cedric Soares due to a hamstring injury, with Jeremy Pied expected to line up at right-back once again. Striker Shane Long is a doubt with a calf problem, meaning that Charlie Austin is likely to start up top after scoring to rescue a point against Bournemouth last time out.
Arsenal: The 'Gunners' will be without Germany international Shkodran Mustafi after he picked up a thigh injury in the defeat to Manchester United last week. Long-term absentee Santi Cazorla is the only other player on the sidelines for Arsene Wenger's side, with the Arsenal boss expected to recall a hosts of stars after they were rested for the resounding victory over BATE Borisov in the Europa League in midweek.
Mauricio Pellegrino: "We have to create chances to try and find in every single game a different solution, different ways to try to attack.
"I hope Charlie Austin can continue in the same way. He is in great goalscoring form and his confidence is high."
Arsene Wenger: "At the moment we have different worries than the title. After such disappointment [losing to Manchester United], you have to think about winning the next game.
"We are too far from the title at the moment to speak about the title. It's not realistic.
"Let's try to win our next game and over a longer distance see if we can come back."
Did you know?
Arsenal haven't won successive away league games against Arsenal since 1997.
Southampton's 2-0 loss to Arsenal at St Mary's in May was their first defeat against Arsenal in six home league games (W2, D3).
Form:
Possible lineups:
Southampton: Forster, Pied, Van Dijk, Yoshida, Bertrand, Romeu, Lemina, Boufal, Tadic, Redmond, Austin.
Arsenal: Cech, Koscielny, Mertesacker, Monreal, Bellerin, Ramsey, Xhaka, Kolasinac, Ozil, Sanchez, Lacazette.