Ronaldo has an impressive record of nine goals in his last five Champions League opening games.
Manchester City, Galatasaray, Basel, Shakhtar and Sporting Lisbon have all suffered at the hands of the star, with Cypriot side APOEL next in his sights.
The 32-year-old will go into the game well rested and eager for action owing to his five-game domestic ban that has prevented him from turning out for Real in the league so far this season.
With Ronaldo hungry and champing at the bit, the stage is set for him to continue his impressive form against a 'lesser side' at the Santiago Bernabeu.
Looking back at his last five Champions League opening games, Ronaldo scored once against Manchester City in the 2012/13 season, three times against Galatasaray in 2013/14, once against Basel in 2014/15, three times against Shakhtar in 2015/16 and once last season against former side Sporting Lisbon.
Can Ronaldo maintain his impressive record tonight?