It all points towards Mourinho lining up the same side as he did at Balaidos. Sergio Romero will play in goal ahead of David De Gea, while no further injuries mean he does not have to make any changes with respect to the first leg.
Celta will also rely on their attacking trio, Pione Sisto, John Guidetti and Iago Aspas, the latter will be granted more freedom to roam around to avoid the intense man-to.man marking he was subject to at Balaidos.
The midfield three will also remain the same for Berizzo's team as they successfully nullified the threat of Paul Pogba the last time around.
Manchester United: Romero; Valencia, Bailly, Blind, Darmian; Fellaini, Ander Herrera, Pogba; Lingard, Mkhitaryan, Rashford.
Celta Vigo: Sergio Álvarez; Hugo Mallo, Cabral, Roncaglia, Jonny; Radoja, Wass, Pablo Hernández; Aspas, Pione Sisto, Guidetti.
Referee: Ovidiu Hategan (Romania)
Stadium: Old Trafford (Manchester)
Time: 20:05 GMT (21:05 CET)