Alexis Sanchez (ARSENAL v Tottenham)
The Chilean is yet to hit top form with Arsenal this season and often cut a frustrated figure in last weekend's 3-1 defeat to Manchester City. The Gunners will be hoping their star man can put in a match-winning performance against arch rivals Spurs, who currently sit third (Arsenal sixth) in the Premier League table.
Romelu Lukaku (MAN UNITED v Newcastle)
Lukaku's bright start to the season has faded, leaving the Belgian without a Premier League goals since the end of September. He will be eager to put that drought behind him when the Red Devils host Newcastle on Saturday evening.
Gylfi Sigurdsson (Crystal Palace v EVERTON)
Much was expected from the Iceland international after his huge £45m move to Everton this summer, but he is yet to hit the high standards he has shown over the last few years at Swansea. A trip to rock-bottom Crystal Palace could prove to be the perfect match to kickstart his Toffees career.
Dejan Lovren (LIVERPOOL v Southampton)
The defender has endured a tough time recently. He was forced to endure disgusting death threats after his performance against Tottenham and was then left out of Liverpool's Premier League match against Huddersfield. The Reds have started to rediscover some of the finest form since that loss to Spurs, meaning Lovren will be keen to get in on the action and prove doubters wrong with a solid performance against former club Southampton.
Moussa Sissoko (Arsenal v TOTTENHAM)
Sissoko has been a peripheral figure at Spurs ever since his £30m move from Newcastle last year, but he is finally starting to get more game time under Mauricio Pochettino. One way the Frenchman could win over the doubtful Tottenham fans would be to produce a commanding display against Arsenal on Saturday.