United will go into the game as favourites and that is reflected in our squad selection, with Liverpool providing just three of the starting XI.
Given Jose Mourinho's celebrated status as a defensive coach, United have the edge at the back, with Jurgen Klopp's free-spirited attacking style providing the creative players.
David De Gea is an obvious choice in goal, with neiher Loris Karius or Simon Mignolet fit to lace his boots.
Antonio Valencia is selected at right-back, whilst we've stuck with the defensive axis that has served United well so far this season in Phil Jones and Eric Bailly.
Left-back proved a tricky selection, with neither side boasting a real quality option so we're punted for Daley Blind, although it could be argued that it is not the Dutchman's best position.
The midfield looks to be a terrifying sight for opposition teams, with Nemanja Matic holding to allow the creative talents of Philippe Coutinho and Paul Pogba to flourish.
Up top there is a mixture of pace, power and flair, with Romelu Lukaku flanked by Sadio Mane and Mohamed Salah.
Do you agree with our team? Let us know in the comments.