Arsenal could draw level with Manchester City, if the Gunners win and Guardiola's men let it slip against West Brom. Both teams come against sides with nothing but their name to play for, with Wenger's men looking to reignite the race for the fourth spot.
Sunderland could fight to go one spot above Middlesbrough, though there is little they can do this season except wait for relegation.
With an 81,6% chance of victory, all the eyes will be set on Arsenal, who could be without star Alexis Sanchez after the Chilean limped off against Stoke.
Possible lineups:
Arsenal: Cech, Holding, Mustafi, Monreal, Bellerín, Xhaka, Ramsey, Gibbs, Ozil, Giroud, Welbeck.
Sunderland: Pickford, Jones, Koné, O’Shea, Manquillo, Denayer, Borini, Honeyman, Ndong, Anichebe, Defoe.