Tottenham ended their Wembley woes with a win over the Borussia Dortmund in gameweek 1 and now come up against the Cypriot champions in Group H.
APOEL:
The home side will be without Lorenzo Ebecilio, George Efrem, Facundo Bertoglio and Zhivko Milanov for the matchup.
Tottenham:
Mauricio Pochettino will travel to Cyprus with a depleted squad due to injuries and suspensions.
Dele Alli and Jan Vertonghen are both banned, while Christian Eriksen is not expected to play a part due to illness.
Victor Wanyama, Mousa Dembele, Danny Rose remain sideline with long-term injuries.
Possible lineups:
APOEL: Waterman; Vouros, Rueda, Carlao, Lago; Sallai, Vinicius, Morais, Aloneftis; De Camargo, Zahid.
Tottenham: Lloris; Alderweireld, Sanchez, Foyth; Aurier, Winks, Dier, Davies; Sissoko, Kane, Son.